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Alprostadil is a medication used to treat impotence (erectile dysfunction) in men and is also intended to identify the possible causes of this disorder. Alprostadil acts by relaxing blood vessels in the muscle walls of the penis, increasing the blood flow to the penile area and therefore inducing an erection.

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Alprostadil, like its contemporaries Edex, Muse and Caverjet, is an impotence agent and vasodilator known as prostaglandin E1. Alprostadil is usually used by men when the blood vessels, nerves and muscles in the penis do not work properly.

This unique medication treats every type of erectile dysfunction - vasculogenic, psychogenic, mixed and neurogenic etiology.

The prostaglandin E1 relaxes the blood vessels and thins the blood, delivering blood flow to the penile area and causing a hard erection.

The main advantage of Alprostadil is its quick action, just 5-10 minutes after injection. The effects last for 30-60 minutes but may vary slightly from patient to patient.

Alprostadil doesn't protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.


Alprostadil is produced in a liquid form and is administered by injecting it directly into the side of the penis. It is important to make sure that you understand how to do this properly. If you are unsure, consult your doctor or healthcare provider.

For the purposes of injecting this medication, always choose a less visible blood vessel. After injecting the medication, apply pressure to the affected area with an alcohol swab for about 5 minutes to avoid bruising.

The injection must not be administrated close to the surface of the skin, at the top or head of the penis or at the base of the penis near the scrotum or testes.

According to the etiology of the erectile dysfunction, the initial dose may vary:

- For vasculogenic or psychogenic erectile dysfunction, or for erectile dysfunction of mixed etiology, the starting dose is 2.5mcg. If there is no effect, you may increase the dose to 5mcg, followed by increments of 5–10mcg until the desired result (dose produces an erection for appropriate sexual intercourse and it doesn't last more than 1 hour). If there is still no response to the initial dose, you may give a second dose of 7.5mcg within one hour, followed by increments of 5–10mcg until the desired result is achieved.

- For erectile disorders of neurogenic etiology, the recommended dose is 1.25mcg. You may increase the second dose to 2.5mcg, and the third dose to 5mcg, followed by increments of 5mcg until the desired result is achieved.

The maximum dose is 60mcg per day. Allow a 24 hour interval between doses.

Use Alprostadil only as needed. Do not take a double dose of Alprostadil.

Missing a dose

Use Alprostadil only as needed, thus missed dosages are not relevant. Do not take a double dose of Alprostadil.


If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately. The overdose of the medication may be followed by feeling light-headed, fainting, having a painful or prolonged erection lasting 4 hours or longer.


Store at the room temperature 25°C (77°F)or below. The medication should be used within 24 hours after opening. Do not freeze it. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

Alprostadil has side effects. The most common are:

  • prolonged or painful erection
  • local bleeding or bruising in the place of injection
  • unusual discharge from the penis
  • pain in the groin, penis or urethra
  • headache
  • dizziness
  • stuffy nose
  • rash on the skin of the penis

Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Alprostadil if you are allergic to any of its components or to other prostaglandins.

Do not take Alprostadil if you have blood problems such as sickle cell anemia or sickle cell trait, leukemia.

You should not be treated with Alprostadil injection if you have penile implants.

Do not take Alprostadil if you have penile problems, e.g. a curved or deformed penis.

Do not use Alprostadil if you have multiple myeloma or other bone marrow problems.

Do not take Alprostadil if you take other medicines for the treatment of erectile problems.

Consult your doctor or health care professional immediately if the erection lasts longer than 4 hours or if it becomes painful.

Alprostadil is not a protector from sexually transmitted diseases or pregnancy. Avoid having unprotected sex.

Do not share drug needles.

Do not drive or operate machinery while taking the medication.

Avoid consuming alcohol as it may worsen the medication side effects.

Alprostadil does not protect you and your partner from sexually transmitted diseases and pregnancy.

Alprostadil is not for use in women, children or newborns.

Q: What is Alprostadil?

A: Alprostadil like its contemporaries Edex, Muse and Caverjet belongs to the class of impotence agents and vasodilators and is called prostaglandin E1. It is used to treat erectile problems in men and to provide them with an erection.

Q: How does Alprostadil work?

A: The medication expands the blood vessels, nerves and muscles of the penis, increasing the blood flow to it, causing an erection.

Q: What are the possible side effects of Alprostadil?

A: Alprostadil has its common side effects which may be followed by a prolonged and painful erection, local bleeding or bruising in the place of injection, unusual discharge from the penis, pain in the groin, penis or urethra, headache, dizziness, rash on the skin of the penis. If you experience negative effects from the medication, you should contact your doctor, the pharmacist or health care provider immediately.

Q: What other drugs will affect Alprostadil Injection?

A: Blood pressure medication or blood thinner such as heparin and warfarin (e.g. Coumadin, Jantoven) may adversely interact with Alprostadil.

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