ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 24: Issue 1 (Mar 2025): Primary and Secondary Glomerular Diseases is now available online.
Biopsy might identifying renal disease related to MM which justify treatment. We have seen light chain tubulopathy with minimal or no proteinuria. ...
View DiscussionIt would be unusual for such as slow progression. ------------------------------ Nelson Leung MD Mayo Clinic Rochester MN (507) 208-1459 --------...
View DiscussionDear all, I will like to ask your help with this patient. She is still in remission only with induction treatment that i previous described. The...
View DiscussionI agree fully with Dr. Rodby and Dr. Rubin on the importance of "team management" in this complex case. The patients desires and wishes for future ...
View DiscussionDr. Leung. Thanks . Just curious. Why would you not consider this case as having Light Chain Cast Nephropathy secondary to a light chain MM? ----...
View Discussion@Roger Rodby Thank you for asking my opinion. This is clearly a complex case which requires expertise and team effort. It cannot and should not b...
View Discussion"Actually with active cancer now, he's not a candidate for future Transplant anymore and we will be managing him most likely in future" I would s...
View DiscussionThanks @Richard Glassock. It depends a lot on whether this patient is a good candidate for chemotherapy. With little albuminuria, I would probably ...
View DiscussionWith a creatinine of 5 his urine ratios are unlikely to be reliable. However he does have hypoalbuminemia. I would not be keen on further immunosup...
View DiscussionActually with active cancer now, he's not a candidate for future Transplant anymore and we will be managing him most likely in future -----------...
View DiscussionWith all due respect to the sincere attention you are giving him, Why are you trying to manage this, shouldn't his transplant center team take c...
View DiscussionAfrican-American gentleman. Age 77, got kidney transplant in April, 2017 because of probable hepatitis C virus associated glomerulonephritis and ty...
View DiscussionThis thread began with a question about possible contraindications for kidney biopsy in the presence of asymptomatic bacteruria and pyuria. In my o...
View DiscussionHello everybody. I apologize for answering after such a long time. To answer the questions that you asked me, the patient did receive Tacrolimu...
View DiscussionI agree with the comments about myeloma and biopsy reiterate that from what I think we've been told the protein in the urine is albumin suspe...
View DiscussionThanks Dr. Leung. If you think this is a LC MGUS, with a serum creatinine at the 3 level, but with little albumin in urine would you still do a kid...
View DiscussionIn general the relation between CFHR deletions and complement mediated HUS is through the production of anti CFH antibodies. I am not aware of any ...
View DiscussionAs Dr. Rodby and others have said, if this multiple myeloma, a biopsy is probably not going to change the management unless it is amyloidosis which...
View DiscussionWhat was the initial serum kappa free light chain level? If over 500mg/L the diagnosis of Myeloma Cast Nephropathy is very likely. This patient nee...
View DiscussionIf a diagnosis of MM is made I do not see a reason for a kidney biopsy bc the treatment is for MM, not the pattern of renal involvement. Havin...
View DiscussionYou can continue spironolactone and even escalate the dose to 50 mg /day as far as serum K [More]
View DiscussionAlthough her A1C is 5.8, however, her OGTT is within normal limits and has no evidence of increased risk for diabetes as evidenced by calculated an...
View DiscussionThis elderly patient presents with recent worsening kidney function, accelerated hypertension with spontaneous hypokalemia suggesting possibly seco...
View DiscussionI strongly recommend biopsy in this case if he can safely be taken off of his anti-platelet agents for the following reasons: The diagnosis of m...
View DiscussionThe most recent KDIGO guidelines recommend using a risk calculator to assess the donor's risk and having a cut-off acceptable to the individual cen...
View DiscussionMy answer is only pertaining to genotype of the donor. Birth weight and nephron number aside, she should not be excluded. Risk for the recipient is...
View DiscussionThanks very much for the incredibly prompt responseCheersShlomo -- Shlomo Cohney FASN PhD FRACP MRCP MBBS Physician/Nephrologist/Transplant Immu...
View DiscussionHer BMI is 29.97, had 2 pregnancies but no gestational Diabetes. We did OGTT since she had HbA1c 5.8, her Fasting was 90 mg/dl and two hours glucos...
View DiscussionPresumably he has IHD and AF (clopidogrel & apixaban) He is on a lot of pills ! Yet he is not on any RAAS blockade He likely has significant reno...
View DiscussionThus is eGFR -by the EKFC equation, not mGFR, but these values should be pretty close to mGFR. (see Astley, M, et al Kidney Int, 2025) ...
View DiscussionMany of us (in Australia) are hesitant/reluctant when considering younger donors and especially in a child to parent situation If as I understand ...
View DiscussionThe median eGFR for 40-45 year old healthy female is 100ml/min/173m2. An eGFR of 80ml/min /1.73m2 is at the lower limit of "normal" . I agree wit...
View DiscussionAverage GFR in age 40-49 is 80-100 ml/min-1.73-so 80 is lower limit for normal but many LKD programs prefer > 90 in donors with potential longer li...
View DiscussionI have to find out what was her birth weight. However, my understanding from reviewing literature evaluating normal GFR in general population, is t...
View DiscussionIn addition to the genetic concerns mentioned above, a 44 year-old donor with a GFR is 81 ml/min/1.73. Would cause me to recommend against acceptan...
View DiscussionHe was started on spironolactone 25 mg daily on 26 March and since then, creatinine has rose from 3.5 to 4.1, a 17% rise, BUN has rose from 41 to 5...
View Discussion13,6grams /d of total urine protein excretion , yet only 3.5milligrams/ d of albumin. Something is wrong here. What is the urinary Immunofixation o...
View DiscussionThis is highly suggestive of LCCN based on high sFLC > 500 mg/l and predominantly non-albumin proteinuria plus kappa light chains predominance. I w...
View DiscussionThanks for additional informations. Blood gas with knowing of blood PH is important in interpretation of acid-base disorders. Because if we have on...
View DiscussionA compound heterozygous (deletion) mutation in CFHR1/3 and CFHR1/ 4 is associated with C3G and anti-Factor H autoantibodies I am eager to learn tge...
View DiscussionPet, scan mentioned above. August, 2024. MRI did not find any bone lesions . April, 2024 and May, 2023 chest x-rays and 2/2023 knee Cray did not fi...
View DiscussionAlthough he has Chronic kidney Disease G3 with recent rise of Creatinine as explained above and Anemia also but for more than 10 years, he has not ...
View DiscussionPersonally, I suggest you contact any of the following individuals for their expert advise: Dr. Richard Smith and/or Dr. Carla Nester at the Univ...
View DiscussionI would love the community's input on the following case: A 44-year-old AA female who is being evaluated as potential donor for her father, who ha...
View DiscussionDr Ali BPH plus UTI with unusual organism. Does he have prostatitis? Incomplete bladder emptying? Tough case. Thank you, Jorge Roman-Latorre MD For...
View DiscussionDoes this patient have Overt MM (satisfying CRAB criteria) or does he have "Smoldering" MM. I can't tell from the data provided. The very low alb...
View DiscussionCRAB - calcium (hypercalcemia, renal (kidney dysfunction), anemia, bone (usually radiographically apparent bone lesions). -----------------------...
View DiscussionThere was no Vomiting . 1-2 days of nausea and stomach discomfort resolved after admission . The only Diuretic that he may be using as outpatient w...
View DiscussionHow would a biopsy change the therapy? ------------------------------ John Mellas MD Nephrology and Hypertension Specialists St Louis MO 31453723...
View DiscussionAny history of repeated vomiting or high dose diuretics use? What doses of NaHCO3 he was on per day? Agree to look for RAS or PA in this setting. ...
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